Va revolutiona oare mangosteenul ,practica medicala a zilelor noastre?

Tot mai multe universitati si centre medicale din intreaga lume studiaza mangostanul cu rezultate din cele mai surprinzatoare.

Am selectat pentru voi citeva din studiile publicate in Biblioteca Nationala Medicala a SUA.
Va invit sa explorati personal site-ul respectiv : www.pubmed.gov
punind la rubrica search cuvintul : garcinia mangostana sau Xanthone (denumirea stiintifica a fructului si a elementului activ studiat in laborator)
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"Independent Research From Across the World
Regarding Mangosteen’s Impact on Cancer.
Antiproliferation, antioxidation and induction of apoptosis by
Garcinia mangostana (mangosteen) on SKBR3
human breast cancer cell line. J Ethnopharmacol. 2004
Jan;90(1):161-6. Moongkarndi P, Kosem N, Kaslungka S,
Luanratana O, Pongpan N, Neungton N.Department of
Microbiology, Faculty of Pharmacy, Mahidol University, Sri
Ayudthaya Road, Rajdhevee, Bangkok 10400, Thailand.
These investigators found that an extract from the
pericarp of the mangosteen fruit (major component in XanGo)
inhibited the growth of breast cancer cells. They also
showed that the extract had potent antioxidant and cancer
cell death properties. They concluded that the extract
from the pericarp of the mangosteen fruit has potential for
chemoprevention.
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Induction of apoptosis by xanthones from mangosteen
in human leukemia cell lines.
Matsumoto K, Akao Y,
Kobayashi E, Ohguchi K, Ito T, Tanaka T, Iinuma M, Nozawa Y. Gifu International Institute of Biotechnology, 1-1
Naka-Fudogaoka, Kakamigahara, Gifu 504-0838, Japan.
These authors examined the effects of six xanthones
extracted from the pericarps of the mangosteen fruit,
Garcinia mangostana, on the cell growth inhibition of human
leukemia cell line HL60. All xanthones displayed growth
inhibitory effects. Among them, alpha-mangostin (a
xanthone) showed the most potent ability to cause the
cancer cells death.
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Garcinone E, a xanthone derivative, has potent cytotoxic effect against the
patocellular carcinoma cell lines.
Planta Med. 2002 Nov;68(11):975-9. Ho CK, Huang
YL, Chen CC. Department of Medical Research &am p; Education, Veterans General Hospital, Taipei, ROC.
Investigators extracted and purified 6 xanthone compounds
from the rinds (peel) of the fruit of Garcinia mangostana,
mangosteen fruit. The investigators tested this extract on
14 different human liver cancer cell lines. Several
chemotherapeutic agents (drugs) were included in the study
for comparison. The results showed that one of the
xanthone derivatives which could be identified as “garcinone
E” has potent cytotoxic effect (kill cells) on all liver
cancer cell lines as well as on the other gastric and lung
cancer cell lines included in the screen. The
investigators suggested that “garcinone E” may be potentially
useful for the treatment of certain types of cancer.
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Alpha-mangostin induces Ca(2+)-ATPase-dependent
apoptosis via mitochondrial pathway in PC12 cells.
J Pharmacol Sci. 2004 May;95(1):33-40. Sato A, Fujiwara H,
Oku H, Ishiguro K, Ohizumi Y. Department of Pharmaceutical
Molecular Biology, Graduate School of Pharmaceutical
Sciences, Tohoku University, Sendai, Japan.
The researchers investigated the cell death effects of
eight xanthones on pheochromocytoma (cancer) cells. Among
these compounds, alpha-mangostin, from the fruit hull of
Garcinia mangostana L. (mangosteen fruit), had the most
potent effect with apoptosis (death) of these cells.--------------------------------------------------------------------------------Xanthones as inhibitors of growth of human cancer cell lines and their effects on the
proliferation of human lymphocytes in vitro.
Bioorg Med Chem. 2002
Dec;10(12):3725-30. Pedro M, Cerqueira F, Sousa ME,
Nascimento MS, Pinto M. Centro de Estudos de Quimica
Organica, Fitoquimica e Farmacologia da Universidade do
Porto, Faculdade de Farmacia, Porto, Portugal.
Twenty-seven xanthones were assessed for their capacity to
inhibit the in vitro the growth of three human cancer cell
lines, (breast cancer, renal cancer, melanoma). Inhibition
of growth of these cancer cell lines depended on the type of
xanthone used in the study.
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Xanthone derivatives as potential anti-cancer drugs.
J Pharm Pharmacol. 1996 May;48(5):539-44. Lin CN, Liou SJ,
Lee TH, Chuang YC, Won SJ. School of Pharmacy, Kaohsiung
Medical College, Taiwan, Republic of China.Researchers showed xanthone derived compounds to have
potent anti- tumor activities against human cancer cells.
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Gamma-pyrone compounds as potential anti-cancer drugs.
J Pharm Pharmacol. 1993 Sep;45(9):791-4. Liou SS,
Shieh WL, Cheng TH, Won SJ, Lin CN. Natural Products
Research Center, Kaohsiung Medical College, Taiwan,
Republic of China.Researchers studied several compounds and found xanthones
with enhanced anti-tumor activity against
human cancer cell lines."